Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1982 Dec;102(4):615-25.
doi: 10.1093/genetics/102.4.615.

Marker-dependent recombination in T4 bacteriophage. I. Outline of the phenomenon and evidence suggesting a mismatch repair mechanism

V P Shcherbakov, L A Plugina, E A Kudryashova, O I Efremova, S T Sizova, O G Toompuu

Marker-dependent recombination in T4 bacteriophage. I. Outline of the phenomenon and evidence suggesting a mismatch repair mechanism

V P Shcherbakov et al. Genetics. 1982 Dec.

Abstract

In standard crosses, some rIIB mutants of T4 phage were found to be susceptible to an extra recombination mechanism to which the other mutants were much less susceptible. The following observations were interpreted as evidence for the mismatch-repair nature of the phenomenon: (1) Marker-dependent recombination generates exclusively double exchanges at both sides of the marker. (2) Marker-dependent recombination is highly sensitive to DNA base sequence at the site of the marker and to that at the corresponding site on the chromosome of the other parent. (3) Within certain limits, the contribution of the marker-dependent mechanism to the total recombination frequency is distance-independent and thus constitutes a constant component.

PubMed Disclaimer

References

    1. J Theor Biol. 1980 Feb 7;82(3):497-520 - PubMed
    1. J Mol Biol. 1981 Jul 5;149(3):337-76 - PubMed
    1. Genetics. 1965 Jan;51:63-75 - PubMed
    1. Genetics. 1971 Nov;69(3):317-37 - PubMed
    1. Mol Gen Genet. 1970;109(4):309-22 - PubMed