Cytoarchitectonic sexual dimorphisms of the medial preoptic and anterior hypothalamic areas in guinea pig, rat, hamster, and mouse

Abstract

A cytoarchitectonic analysis is presented of a configuration of cells which extends through the medial preoptic and rostral part of the anterior hypothalamus of the guinea pig, rat, hamster, and mouse. Within that configuration, called here the sexually dimorphic nuclear complex of the medial preoptic-anterior hypothalamic area (SDNC-MPAH), there is nearly continuous variation in cellular distribution or packing density as one proceeds rostrocaudally, as well as variations between females and males at corresponding levels. The major cell groups comprising SDNC-MPAH are the medial preoptic nucleus (MP) and the preventricular portion of the periventricular nucleus (Pep) rostrally, and the anterior hypothalamic nucleus (AH), anterior portion of periventricular nucleus, (Pea), and bed nucleus of stria terminalis (ST) caudally. The most striking cytoarchitectonic dimorphisms usually involve MP and AH. In all four species examined, MP is larger and, except for the mouse, appears to be more densely cellular in the female than in the male. Most prominently in the rat and guinea pig, AH is densely cellular throughout in the female, including the subependymal zone, whereas in the male AH lies at a distance from the third ventricle, separated from the ependyma by a cell-poor zone. The significance of these findings may lie in the fact that the region exhibiting the sexual dimorphisms has been shown to be involved in the regulation of reproductive functions which are sexually differentiated and developmentally influenced by the fetal or perinatal hormonal milieu in some species.