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Comparative Study
. 1980 Jan;96(1):43-51.
doi: 10.1007/BF00412896.

[Tumor inhibition by metallocenes: effect of titanocene, zirconocene, and hafnocene dichlorides on Ehrlich ascites tumor in mice (author's transl)]

[Article in German]
P Köpf-Maier, B Hesse, H Köpf
Comparative Study

[Tumor inhibition by metallocenes: effect of titanocene, zirconocene, and hafnocene dichlorides on Ehrlich ascites tumor in mice (author's transl)]

[Article in German]
P Köpf-Maier et al. J Cancer Res Clin Oncol. 1980 Jan.

Abstract
in English, German

The antitumor activity of the metallocene dichlorides TDC, ZDC, and HDC against Ehrlich ascites tumor in CF1 mice is investigated. A single i.p. injection of TDC in the optimum dose (30-60 mg/kg) 24 h p.t.t. achieves survival of 80-90% of the animals until day 180 p.t.t. without any tumor manifestation. This indicates an increase in the mean survival time of about 900% referred to the untreated animals. In contrast, ZDC and HDC exhibit no recognizable antineoplastic properties under equal experimental conditions. Assuming a similar mechanism of tumor inhibition for both DDP and the antineoplastic active metallocene dichlorides TDC, VDC, and MDC the comparatively increased non bonding Cl...Cl distance ("bite") of ZDC and HDC may be responsible for cancerostatic inactivity of the latter compounds.

Die Antitumor-Aktivität der Metallocen-dichloride TDC, ZDC und HDC wird an Ehrlich-Aszites-Tumor-tragenden CF 1-Mäusen untersucht.

Nach einmaliger i.p.-Injektion von TDC in optimaler Dosis (30–60 mg/kg) 24 h p.t.t. überleben 80–90% der Tiere bis zum 180. Tag p.t.t. ohne Tumormanifestation. Dies bedeutet eine Zunahme der mittleren Überlebensdauer um etwa 900% gegenüber den unbehandelten Kontrolltieren. ZDC und HDC hingegen weisen unter gleichen Versuchsbedingungen keine erkennbaren tumorhemmenden Eigenschaften auf. Nimmt man einen ähnlichen Wirkungsmechanismus für DDP und die cancerostatisch aktiven Metallocen-dichloride TDC, VDC und MDC an, so kann der deutlich größere nicht-bindende Cl... Cl-Abstand (“bite”) von ZDC und HDC mit der cancerostatischen Unwirksamkeit der letztgenannten Verbindungen in Zusammenhang gebracht werden.

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