[A method for the determination of liver alkaline phosphatase in feces and their activity in intra- and extrahepatic cholestasis (author's transl)]
- PMID: 7192030
[A method for the determination of liver alkaline phosphatase in feces and their activity in intra- and extrahepatic cholestasis (author's transl)]
Abstract
Using precipitating antibodies to human liver alkaline phosphatase (L-AP), a quantitative method is evaluated for the determination of L-AP-activity in feces. Normal controls (n = 42) exhibit a logarithmic normal distribution. Patients with intrahepatic cholestasis (n = 36) demonstrate an increase, patients with extrahepatic cholestasis (n = 23) a decrease of the fecal L-AP-activity. Variations of fecal L-AP-activities due to a varying water content of the stools could be excluded by simultaneous determination of intestinal AP-activity. Prae- and postoperative determinations in 12 patients with extrahepatic cholestasis yielded an increase of L-AP-activity after reconstructive surgery. In intrahepatic cholestasis, high fecal L-AP-activities are found together with relative low total AP-activities in the serum whereas in extrahepatic cholestasis low fecal L-AP-activities are associated with relative high total AP-activities in the serum.
Similar articles
-
[Alkaline phosphatases in human feces, intestinal mucosa and bile, and the occurrence of 5'-nucleotidase in feces (author's transl)].Z Klin Chem Klin Biochem. 1975 Oct;13(10):437-44. Z Klin Chem Klin Biochem. 1975. PMID: 858 German.
-
Fecal intestinal alkaline phosphatase in coeliac disease.Z Gastroenterol. 1980 Jul;18(7):381-8. Z Gastroenterol. 1980. PMID: 7424078
-
The clinical significance of serum alkaline phosphatase isoenzymes in locomotor diseases.Z Rheumatol. 1975 Jul-Aug;34(7-8):261-9. Z Rheumatol. 1975. PMID: 1058609
-
Lipoprotein-X in patients with cirrhosis: its relationship to cholestasis and hypercholesterolemia.Hepatology. 1998 Nov;28(5):1199-205. doi: 10.1002/hep.510280506. Hepatology. 1998. PMID: 9794902
-
Histopathology of cholestasis.Verh Dtsch Ges Pathol. 1995;79:233-40. Verh Dtsch Ges Pathol. 1995. PMID: 8600686 Review.
Cited by
-
Differentiation of human alkaline phosphatases by lectin binding affinity.Klin Wochenschr. 1980 Sep 15;58(18):947-51. doi: 10.1007/BF01477053. Klin Wochenschr. 1980. PMID: 7206590
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical
Research Materials