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Clinical Trial
. 1977 Mar;39(3):1026-31.
doi: 10.1002/1097-0142(197703)39:3<1026::aid-cncr2820390305>3.0.co;2-p.

Therapy of advanced squamous carcinoma of the lung: cyclophosphamide vesus "COMB"

G P Bodey, S W Lagakos, A C Gutierrez, H E Wilson, O S Selawry
Clinical Trial

Therapy of advanced squamous carcinoma of the lung: cyclophosphamide vesus "COMB"

G P Bodey et al. Cancer. 1977 Mar.

Abstract

The four-drug combination of cyclophosphamide, vincristine, methyl CCNU and bleomycin was compared to CTX alone in a prospective randomized trial. Only one of 20 patients treated with COMB and one of 27 patients treated with CTX achieved a partial response. CTX was associated with a significantly better survival than COMB among patients who were ambulatory at onset of therapy. Survival among non-ambulatory patients was similar with both regimens.

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