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. 1981 May 22;212(4497):923-4.
doi: 10.1126/science.7195067.

Tumor shedding and coagulation

H F Dvorak, S C Quay, N S Orenstein, A M Dvorak, P Hahn, A M Bitzer, A C Carvalho

Tumor shedding and coagulation

H F Dvorak et al. Science. .

Abstract

Three syngeneic carcinomas from two species shed plasma membrane vesicles when cultured in vitro or grown in the ascites tumor form in vivo. Shed vesicles carry procoagulant activity that can account for the activation of the clotting system and the fibrin deposition associated with these and many other types of malignancy in animals and man.

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