[Ethanol elimination in rats with different levels of alcoholic motivation]

Abstract

It has been established during intraperitoneal and oral administration of ethanol to white rats in a test dose of 1 g/kg that in the animals with high alcoholism motivation, the rate of alcohol elimination from blood is fairly high, while the species with low alcoholic motivation are marked by a slower ethanol elimination. In rats with high alcohol motivation, the time of ethanol anesthesia significantly exceeds that in the animals with low alcoholic motivation. The blood levels of ethanol at the moment of wake up are identical in both groups. A conclusion is made about the relationship between the elimination pattern, activity of alcohol-metabolizing enzymatic systems and predisposition to alcoholism.