Sensitization to the behavioral effects of cocaine: modification by Pavlovian conditioning

Abstract

Sensitization to the behavioral effects of cocaine was more pronounced following drug administration in the presence of cues previously associated with cocaine administration than in their absence. Furthermore, sensitization was attenuated by repeated presentations of the usual predrug cues followed only by saline, i.e. sensitization was extinguishable. These findings indicate that Pavlovian conditioning contributes to sensitization, and have implications for treatment of stimulant abuse.