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Case Reports
. 1981 Oct;137(2):237-42.
doi: 10.1007/BF00441325.

Intrauterine growth retardation. A report of two cases with bird-headed appearance, skeletal changes and peripheral GH resistance

B Boscherini, G Iannaccone, C La Cauza, G Mancuso, F Girotti, G Finocchi, A M Pasquino
Case Reports

Intrauterine growth retardation. A report of two cases with bird-headed appearance, skeletal changes and peripheral GH resistance

B Boscherini et al. Eur J Pediatr. 1981 Oct.

Abstract

Two cases of severe intrauterine growth retardation, a boy and a girl studied for 7 and 10 years respectively, are reported. Both patients showed peculiar cranio-facial abnormalities as observed in the so-called Seckel's syndrome, an appearance of premature aging, peripheral GH resistance which was probably due to deficiency in Somatomedin A production, sella areas and volumes consistently at the upper limits of normal when related to the patients' height, and dysharmonic skeletal maturation ivory cone-shaped epiphyses of the tubular bones of the hands.

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