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Case Reports
. 1982 Mar;32(3):308-11.
doi: 10.1212/wnl.32.3.308.

Neurologic manifestations of podophyllin toxicity

C M Filley, N R Graff-Richard, J R Lacy, M A Heitner, M P Earnest
Case Reports

Neurologic manifestations of podophyllin toxicity

C M Filley et al. Neurology. 1982 Mar.

Abstract

A young woman presented with podophyllin intoxication following topical application of podophyllin resin to genital condylomata acuminata. The disorder was marked by hallucinatory psychosis, bone marrow depression, and mild hepatic dysfunction. The psychosis and systemic disturbances resolved within 3 weeks, but were followed by autonomic and sensorimotor peripheral neuropathy. This case illustrates the transient central neurotoxicity and persistent peripheral neurotoxicity of podophyllin.

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