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. 1982 Feb;19(1):8-15.
doi: 10.1136/jmg.19.1.8.

An epidemiological and genetic study of facial clefting in France. I. Epidemiology and frequency in relatives

C Bonaiti, M L Briard, J Feingold, B Pavy, J Psaume, G Migne-Tufferaud, J Kaplan

An epidemiological and genetic study of facial clefting in France. I. Epidemiology and frequency in relatives

C Bonaiti et al. J Med Genet. 1982 Feb.

Abstract

The frequencies of cleft lip with or without cleft palate (CL(P)) and isolated cleft palate (CP) have been estimated in France to be 0.082% and 0.035%, respectively, after exclusion of malformation syndromes. A genetic and epidemiological study has been carried out on 468 patients with CL(P) and 163 with CP. The results are given in detail and some specific points are discussed: the apparently low incidence in France, the relationship between sex ratio and abortion rates, the maternal effects, and the possibility of an association between CL(P) and CP.

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