doi: 10.1016/0014-2999(80)90426-4.
Inhibition of 5-hydroxytryptamine contraction of guinea-pig smooth muscle treated with black widow spider venom
- PMID: 7202505
- DOI: 10.1016/0014-2999(80)90426-4
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Inhibition of 5-hydroxytryptamine contraction of guinea-pig smooth muscle treated with black widow spider venom
Eur J Pharmacol.
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Abstract
Black widow spider venom (BWSV) elicited a prolonged tonic contraction of guinea-pig ileum which abolished the nicotine-induced contraction; however, the subsequent acetylcholine stimulation was found to be unchanged. These findings indicate a depletion of nerve terminal transmitters caused by BWSV without a disruption of the muscle contractile mechanism. Following the BWSV-induced contraction, the stimulation to 5-hydroxytryptamine (5-HT) was found to be abolished. This abolishment indicates a mediation of 5-HT-induced smooth muscle contraction in the nerve rather than the muscle.
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