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. 1981 Jan 16;69(2):221-4.
doi: 10.1016/0014-2999(81)90419-2.

Analgesic properties of the GABA-mimetic THIP

R C Hill, R Maurer, H H Buescher, D Roemer

Analgesic properties of the GABA-mimetic THIP

R C Hill et al. Eur J Pharmacol. .

Abstract

The analgesic properties of the muscimol analogue THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) in laboratory animals were compared with those of baclofen, morphine and muscimol. THIP was active orally and parenterally and resembled muscimol qualitatively in its actions. Quantitatively, THIP and baclofen were 2--3 times less potent than morphine and 5--15 times less potent than muscimol. The analgesic effects of THIP, baclofen and muscimol were not reversed by naloxone or bicuculline.

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