Q- and C-band polymorphisms in patients with ovarian or breast carcinoma

Abstract

To establish the significance of the Q- and C-band variants in risk for malignant disease, chromosome analysis was carried out in 37 women with carcinoma of the ovary or breast and in 40 controls. The frequencies of brilliant fluorescence in segments 3p11q11, 4p11q11, 13p11, 13p13, 14p11, 14p13, 15p11, 15p13, 21p11, 21p13, 22p11 and 22p13, the mean numbers of the brilliant fluorescent segments per cell per individual, and the frequency of inversions of the brilliant fluorescent centromeric area of chromosome 3 were established. The absolute and relative lengths of C bands in chromosomes 1,9, and 16 and the frequencies of C-band size heteromorphisms and inversions were determined. The results of the investigation indicate that the presence of Q and C variants is not associated with an elevated risk of ovarian and breast carcinoma.