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. 1978 Nov 1;52(1):129-32.
doi: 10.1016/0014-2999(78)90031-6.

Influence of GABA receptor agonists and antagonists on the binding of 3H-diazepam to the benzodiazepine receptor

M S Briley, S Z Langer

Influence of GABA receptor agonists and antagonists on the binding of 3H-diazepam to the benzodiazepine receptor

M S Briley et al. Eur J Pharmacol. .

Abstract

The GABA receptor agonists, GABA and muscimol, increased, while the GABA receptor antagonist, (+)-bicuculline, decreased the affinity of the benzodiazepine receptor for 3H-diazepam. The effect was seen at both 0 and 25 degrees C in spite of a large difference of affinity for 3H-diazepam at the two temperatures.

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