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. 1981 Mar;67(3):903-6.
doi: 10.1172/jci110108.

Human platelet stimulation by acetyl glyceryl ether phosphorylcholine

L M McManus, D J Hanahan, R N Pinckard

Human platelet stimulation by acetyl glyceryl ether phosphorylcholine

L M McManus et al. J Clin Invest. 1981 Mar.

Abstract

Acetyl glyceryl ether phosphorylcholine (AGEPC) induced dose-dependent platelet aggregation and release of [3H]serotonin and platelet factor 4 in citrated human platelet-rich plasma. ADP scavengers or indomethacin prevented irreversible platelet aggregation responses induced by 0.2 microM AGEPC but had no effect upon platelet secretion; prostacyclin inhibited AGEPC-induced aggregation and secretion. EDTA or EGTA inhibited AGEPC-induced aggregation but had no effect on platelet secretion.

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