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. 1978 Sep 15;34(9):1122-3.
doi: 10.1007/BF01922904.

The isolation and structure of 13,18-dehydroglaucarubinone, a new antineoplastic quassinoid from Simarouba amara

J Polonsky, Z Varon, H Jacquemin, G R Pettit

The isolation and structure of 13,18-dehydroglaucarubinone, a new antineoplastic quassinoid from Simarouba amara

J Polonsky et al. Experientia. .

Abstract

An investigation of the Guyana plant Simarouba amara Aubl. (Simaroubaceae) for antineoplastic quassinoids led to isolation and structural determination of the new quassinoids 2'-acetylglaucarubine (1a) and 13,18-dehydroglaucarubinone (2). The previously known 2'-acetylglaucarubinone (3a) and glaucarubinone (3b) were also obtained. The new quassinoid 2 was found significantly to inhibit growth of the murine lymphocytic leukemia P388.

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References

    1. J Org Chem. 1975 Mar 7;40(5):654-6 - PubMed
    1. J Pharm Sci. 1975 Dec;64(12):2023-4 - PubMed
    1. Fortschr Chem Org Naturst. 1973;30:101-50 - PubMed

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