[Immune reactions in pseudo-lupus-syndrome. A long-term study (author's transl)]

Abstract

23 patients with proven pseudolupus-syndrome were observed over a period of five years; titers of specific antimitochondrial antibodies (AMA) were tested in a follow-up study after the last intake of Venopyronum-Dragees (VPD), a drug combination of plant glycosides, horse-chestnut extracts and phenopyrazone. Cellular immune reactions against the eliciting drug, depended on the date of the acute phase and were examined in two patients after reexposure. High titers in the acute phase decreased rapidly in most of the cases within the first six months. After reexposure with VPD, AMA rose within three days up to the five fold compared with the initial titer. Only the analgetic component of VPD, phenopyrazone, was able to induce a significant increase of AMA-titer after reexposure. A specific cellular sensitivity to this substance could be demonstrated by lymphocyte stimulation in the presence of a phenopyrazone containing drug preparation. There was no chronic course of the disease; clinical exazerbation could be observed only after new intake of the drug. The analysis of drug history shows, that other pyrazolone containing drugs may also be able to induce a pseudolupus-syndrome.