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. 1978 Dec;15(6):487-9.
doi: 10.1007/BF02342875.

Growth hormone enhances basement membrane thickening in experimental diabetes. A preliminary report

R Osterby, K Seyer-Hansen, H J Gundersen, K Lundbaek

Growth hormone enhances basement membrane thickening in experimental diabetes. A preliminary report

R Osterby et al. Diabetologia. 1978 Dec.

Abstract

Injection of porcine growth hormone (200 microgram) or saline 5 days a week for 16 to 20 weeks in streptozotocin-diabetic rats showed that compared to saline growth hormone produced a 2 1/2-fold larger increase in glomerular capillary basement membrane thickness (2p = 0.027). The possible significance of this effect of an elevated level of growth hormone for diabetic microangiopathy is discussed.

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