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. 1981 Jan 1;21(1):39-43.
doi: 10.1016/0304-3940(81)90054-9.

Amygdaloid kindling enhances the enkephalin content in the rat brain

O Vindrola, R Briones, M Asai, A Fernández-Guardiola

Amygdaloid kindling enhances the enkephalin content in the rat brain

O Vindrola et al. Neurosci Lett. .

Abstract

Established amygdaloid kindling causes an increase in the immunoassayable content of both Leuenkephalin and Met-enkephalin in the rat brain. Control and sham-operated (electrode implanted but not stimulated) rats do not show statistically significant differences in brain enkephalin content, while kindled rats show a 40% enkephalin increase in both hemispheres. The present finding is in agreement with several lines of evidence and suggest that enkephalins may play a role in epileptic seizures.

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