Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1981 Jan 24;9(2):365-73.
doi: 10.1093/nar/9.2.365.

Transcriptional errors and ambiguity resulting from the presence of 1,N6-ethenoadenosine or 3,N4-ethenocytidine in polyribonucleotides

S Spengler, B Singer
Free PMC article

Transcriptional errors and ambiguity resulting from the presence of 1,N6-ethenoadenosine or 3,N4-ethenocytidine in polyribonucleotides

S Spengler et al. Nucleic Acids Res. .
Free PMC article

Abstract

1,N6-Ethenoadenosine (epsilon A) and 3,N4-Ethenocytidine (epsilon C) in copolymers with unmodified nucleosides were transcribed using DNA-dependent RNA polymerase in the presence of Mn2+. Nearest neighbor analysis of the products showed that epsilon A directed incorporation of A much greater than U greater than C while epsilon C directed the incorporation of U greater than or equal to A much greater than C Neither directed G into the complementary polymer. Such misincorporations resulting from epsilon A and epsilon C, compounds that are formed in vivo by the carcinogen vinyl chloride, may have a biological role as promutagens.

PubMed Disclaimer

References

    1. Biochemistry. 1970 Sep 15;9(19):3694-701 - PubMed
    1. Biochem Biophys Res Commun. 1972 Jan 31;46(2):597-604 - PubMed
    1. Biochim Biophys Acta. 1973 Apr 21;308(7):28-34 - PubMed
    1. J Am Chem Soc. 1974 Feb 20;96(4):1205-12 - PubMed
    1. Biochemistry. 1974 Nov 19;13(24):4869-78 - PubMed

Publication types