doi: 10.1126/science.7209515.
Vasopressin analogs that antagonize antidiuretic responses by rats to the antidiuretic hormone
- PMID: 7209515
- DOI: 10.1126/science.7209515
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Vasopressin analogs that antagonize antidiuretic responses by rats to the antidiuretic hormone
Science.
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Abstract
Four new synthetic analogs of vasopressin (antidiuretic hormone) can antagonize the antidiuretic response to intravenous vasopressin in anesthetized, water-loaded rats. They also cause a diuresis resembling that of diabetes insipidus when given intraperitoneally to conscious rats. Such antagonists may prove to be useful both pharmacologically and therapeutically.
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