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. 1981 Apr 3;212(4490):49-51.
doi: 10.1126/science.7209515.

Vasopressin analogs that antagonize antidiuretic responses by rats to the antidiuretic hormone

W H Sawyer, P K Pang, J Seto, M McEnroe, B Lammek, M Manning

Vasopressin analogs that antagonize antidiuretic responses by rats to the antidiuretic hormone

W H Sawyer et al. Science. .

Abstract

Four new synthetic analogs of vasopressin (antidiuretic hormone) can antagonize the antidiuretic response to intravenous vasopressin in anesthetized, water-loaded rats. They also cause a diuresis resembling that of diabetes insipidus when given intraperitoneally to conscious rats. Such antagonists may prove to be useful both pharmacologically and therapeutically.

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