[Studies on specific markers of hormone-dependence in endometrial carcinoma : estradiol receptors and uterine peroxidase (author's transl)]

Abstract

Both cytosol estradiol-17 beta (E2) receptors and uterine peroxidase were detected in normal uterine tissues of rat and hamster, however, they were not detected when the tissues were cultivated in vitro. Uterine peroxidase was specifically induced by the administration of E2 in these normal uterine tissues in vivo. On the other hand, malignant tissues formed by the transplantation of uterine and mammary adenocarcinoma cells showed hormone-independence. Neither cytosol E2 receptors nor peroxidase was detected in these malignant tissues. These results indicate that, in addition of E2 receptors, peroxidase induction by E2 is a specific marker for hormone-dependence in both normal and abnormal uterine tissues.