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. 1981 Jan;11(1):15-8.
doi: 10.1111/j.1365-2125.1981.tb01095.x.

Clinical trials, reviews, and the Journal of Negative Results

C Maxwell

Clinical trials, reviews, and the Journal of Negative Results

C Maxwell. Br J Clin Pharmacol. 1981 Jan.

Abstract

1 Eighteen our of twenty non-significant placebo controlled trials are shown to have trends favouring imipramine and are consistent with a further ten significant at 0.05. 2 The problems of falsely positive and falsely negative results are discussed. A plea is made to medical journal editors to publish 'negative' or null difference trials by title only; rather than not at all.

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