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. 1981 Jan;11(1):53-6.
doi: 10.1111/j.1365-2125.1981.tb01101.x.

Inhibition of gastric acid secretion with a mast cell stabiliser, FPL-52694

H A Davies, J Rhodes, M Thomas

Inhibition of gastric acid secretion with a mast cell stabiliser, FPL-52694

H A Davies et al. Br J Clin Pharmacol. 1981 Jan.

Abstract

1 The effect on gastric acid secretion of a mast cell stabiliser FPL-52694 was examined in nine healthy volunteers. 2 The compound which is moderately well absorbed after oral ingestion, was taken for 5 days prior to the measurement of acid secretion and was also given intravenously during part of the gastric test. A submaximal dose of pentagastrin (0.3 microgram/kg/h) was given by intravenous infusion for 2 h in a controlled test and then after administration of FPL-52694. 3 There was a significant reduction (37%) in acid secretion during the second test which was probably due to the effect of the compound on mast cell degranulation in the gastric mucosa.

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