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. 1981 Mar;11(3):279-85.
doi: 10.1111/j.1365-2125.1981.tb00535.x.

The effect of enzyme induction on the metabolism of disopyramide in man

M L Aitio, L Mansury, E Tala, M Haataja, A Aitio

The effect of enzyme induction on the metabolism of disopyramide in man

M L Aitio et al. Br J Clin Pharmacol. 1981 Mar.

Abstract

1 The effects of rifampicin, phenytoin, and disopyramide treatments on the metabolism of disopyramide were studied in patients and volunteers. 2 Rifampicin treatment markedly increased the metabolism of disopyramide. 3 Phenytoin had effects similar to those of rifampicin. The effect subsided in 2 weeks after stopping the treatment. 4 The metabolism of disopyramide seemed fastest in the patient group with the higher dose of disopyramide. Both in patients and volunteers a significant increase occurred in the urinary mono-N-dealkyldisopyramide/disopyramide ratio during the first week of disopyramide therapy. This change can partly be due to pharmacokinetic differences between disopyramide and its metabolite. The inducing effect of disopyramide remained uncertain.

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