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. 1980 Dec;66(6):920-5.

The in vitro uptake of 14C-praziquantel by cestodes, trematodes, and a nematode

P Andrews, H Thomas, H Weber
  • PMID: 7218112

The in vitro uptake of 14C-praziquantel by cestodes, trematodes, and a nematode

P Andrews et al. J Parasitol. 1980 Dec.

Abstract

14C-praziquantel was rapidly taken up by Schistosoma mansoni, Fasciola hepatica, Hymenolepis nana, and isolated strobilocerci of Taenia taeniaeformis. Schistosoma mansoni lost praziquantel rapidly to drug-free medium. Chromatography of extracts prepared after incubation of S. mansoni and H. nana yielded no indication that praziquantel was metabolized. Autoradiography revealed a uniform distribution of praziquantel throughout the tissues of S. mansoni and H. nana. Uptake was considerably slower in the nematode Heterakis spumosa and apparently via the oral route.

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