Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1978 Oct;8(4):431-4.
doi: 10.1128/jcm.8.4.431-434.1978.

Comparison of immunogenicity of a whole virion and a subunit influenza vaccine in adults

D W Ortbals, H Liebhaber
Comparative Study

Comparison of immunogenicity of a whole virion and a subunit influenza vaccine in adults

D W Ortbals et al. J Clin Microbiol. 1978 Oct.

Abstract

The immunogenicity and reactogenicity of a whole virus (Merck Sharp & Dohme) and a subunit (Wyeth) influenza A/New Jersey/76 vaccine were compared in a group of 214 normal adult subjects. Both the seroconversion rate and the magnitutde of hemagglutination inhibition antibody response were significantly (P less than 0.01) lower in the recipients of the subunit vaccine, whereas there were no significant differences in local or systemic reactions between the two preparations. On the basis of these data, we question the previous Public Health Service recommendation that one dose of either preparation of the influenza A/New Jersey/76 vaccine is equally efficacious in individuals over 24 years of age.

PubMed Disclaimer

References

    1. J Lab Clin Med. 1964 Jan;63:5-13 - PubMed
    1. J Infect Dis. 1976 Dec;134(6):633-8 - PubMed
    1. Am Rev Respir Dis. 1976 Aug;114(2):305-13 - PubMed
    1. J Immunol. 1967 Apr;98(4):800-5 - PubMed
    1. Am J Epidemiol. 1976 Jul;104(1):34-46 - PubMed

Publication types