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. 1981 Apr 9;290(5806):457-65.
doi: 10.1038/290457a0.

Sequence and organization of the human mitochondrial genome

S Anderson, A T Bankier, B G Barrell, M H de Bruijn, A R Coulson, J Drouin, I C Eperon, D P Nierlich, B A Roe, F Sanger, P H Schreier, A J Smith, R Staden, I G Young

Sequence and organization of the human mitochondrial genome

S Anderson et al. Nature. .

Abstract

The complete sequence of the 16,569-base pair human mitochondrial genome is presented. The genes for the 12S and 16S rRNAs, 22 tRNAs, cytochrome c oxidase subunits I, II and III, ATPase subunit 6, cytochrome b and eight other predicted protein coding genes have been located. The sequence shows extreme economy in that the genes have none or only a few noncoding bases between them, and in many cases the termination codons are not coded in the DNA but are created post-transcriptionally by polyadenylation of the mRNAs.

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