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. 1977 Oct 22;2(8043):854-5.
doi: 10.1016/s0140-6736(77)90786-3.

Predicting patients' warfarin requirements

P A Routledge, D M Davies, S M Bell, J S Cavanagh, M D Rawlins

Predicting patients' warfarin requirements

P A Routledge et al. Lancet. .

Abstract

In 34 patients undergoing anticoagulant therapy with warfarin a close relationship has been observed between the logarithm of the 'Thrombotest' response to a loading dose (10 mg/day for three days) and the maintenance dose required to achieve an anticoagulant response of 8-12% (thrombo-test). This relationship appears to be close enough to enable maintenance dosages to be predicted.

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