Influence of dietary unsaturated and saturated fat on the plasma lipoproteins of Mongolian gerbils

Abstract

Lipid and apoprotein moieties of the plasma lipoproteins of Mongolian gerbils (Meriones unguiculatus) were compared in animals fed semipurified diets containing either coconut oil (COC) or safflower oil (SAF). COC-induced hypercholesterolemia was associated with elevations in very low density lipoprotein (VLDL), low density lipoprotein (LDL) and high density lipoprotein (HDL). Saturated fat feeding also resulted in th saturation of fatty acids of triglycerides and cholesteryl esters of VLDL and LDL, but had little effect on HDL fatty acids. Lipoprotein composition and size were not influenced by the type of dietary fat, suggesting that the hypercholesterolemia with saturated fat feeding was due to the circulation of a greater number of lipoprotein particles. The apoproteins of gerbil lipoproteins had molecular weights comparable to other animals. The relative amounts of apoproteins, particularly the apoC peptides, increased with dietary fat saturation.