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. 1981 Feb;62(1):59-64.

Phagocytic cells in glomerular cultures from NZB/W mice

A R McGiven, J S Hunt, W A Day, A E Jackson

Phagocytic cells in glomerular cultures from NZB/W mice

A R McGiven et al. Br J Exp Pathol. 1981 Feb.

Abstract

Comparative studies of glomerular cultures from NZB/W and normal control mice aged 2, 4, 6, 8, 10 and 12 months revealed a significant increase in the number of phagocytic cells in cultures from NZB/W mice at all ages. These cells on electron microscopy had the appearance of macrophages and on immunofluorescence showed Fc receptors and reacted with rabbit anti-mouse macrophage serum. The cells appear to be of blood monocyte origin and it is likely that they play a role in the pathogenesis in NZB/W mice of the glomerulopathy associated with clearance of immune complexes.

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