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. 1981 Mar;16(3):249-54.

Drug effect on blink rates in rhesus monkeys: preliminary studies

C N Karson, R A Staub, J E Kleinman, R J Wyatt
  • PMID: 7225488

Drug effect on blink rates in rhesus monkeys: preliminary studies

C N Karson et al. Biol Psychiatry. 1981 Mar.

Abstract

Various drugs that alter central monoamine activity were given to monkeys to determine effects on blink rate. Chronic pargyline treatment raised the mean +/- SD blink rate slightly to 18.2 +/- 5.3 blinks/90 sec. When phenylethylamine was added to chronic pargyline treatment, blinks increased from a base line of 16.8 +/- 7.6 blinks/90 sec to 37 +/- 15 blinks/90 sec. Apomorphine (0.36 mg/kg) raised blinks from a base lone of 12.2 +/- 2.8 blinks/90 sec. to 41.9 +/- 10.3 blinks/90 sec. and reversed a decrease in blinking caused by haloperidol. The neurochemical basis of blinking and implications for tardive dyskinesia are discussed.

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