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. 1981 Jan;72(1):101-2.
doi: 10.1111/j.1476-5381.1981.tb09111.x.

Spurious effects of commercial preparations of oxytocin on the isolated vas deferens of the rat

J H Botting

Spurious effects of commercial preparations of oxytocin on the isolated vas deferens of the rat

J H Botting. Br J Pharmacol. 1981 Jan.

Abstract

1 The inhibitory effect of a commercial preparation of oxytocin (Syntocinon) was studied on the isolated vas deferens of the rat. 2 The inhibition of contractions to agonists and to field stimulation obtained were mimicked by appropriate dilutions of chlorbutol, a preservative present in Syntocinon. 3 Preservative-free synthetic oxytocin had no inhibitory effect on the tissue and slightly potentiated contractions evoked by field stimulation. 4 It is concluded that inhibitory effects of Syntocinon on the vas deferens are due to chlorbutol, not oxytocin.

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