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. 1981 Apr 6;210(1-2):461-6.
doi: 10.1016/0006-8993(81)90927-6.

Anesthetics and the habenulo-interpeduncular system: selective sparing of metabolic activity

Anesthetics and the habenulo-interpeduncular system: selective sparing of metabolic activity

M Herkenham. Brain Res. .

Abstract

The method of regional localization of brain metabolism by [14C]deoxyglucose during anesthesia in rats shows that pentobarbital, ether and chloral hydrate reduce deoxyglucose uptake in most neuronal regions, with one common exception: spared or increased metabolism is found in the medial habenula, the interpeduncular nucleus, and the habenulo-interpeduncular tract. Prior destruction of afferent inputs abolishes the selective metabolic sparing in the habenulo-interpeduncular system during chloral hydrate anesthesia.

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