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. 1981 May;79(5):552-4.
doi: 10.1378/chest.79.5.552.

Hemodynamic effects of rapid bolus hypertonic sodium bicarbonate

J S Huseby, D G Gumprecht

Hemodynamic effects of rapid bolus hypertonic sodium bicarbonate

J S Huseby et al. Chest. 1981 May.

Abstract

We found that rapid bolus administration of hypertonic sodium bicarbonate in the recommended clinical dose produced significant, though transient, increases in intracranial pressure and decreases in blood pressure in dogs. These effects, which are related to the high osmolarity of the drug (2,000 mOsm/L), are not found when it is administered slowly.

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