doi: 10.1021/jm00208a016.
New synthetic routes to tilorone dihydrochloride and some of its analogues
- PMID: 722716
- DOI: 10.1021/jm00208a016
Item in Clipboard
New synthetic routes to tilorone dihydrochloride and some of its analogues
J Med Chem.
1978 Oct.
Abstract
New synthetic routes to the orally active, interferon-inducing antiviral agent tilorone dihydrochloride, 2,7-bis-[(diethylamino)ethoxy]fluoren-9-one dihydrochloride (1a), were developed. The routes involved the preparation and solvolysis of tetrazonium fluoroborate salts of 2,7-diaminofluoren-9-one. Nonplanar (1b), 9-sulfone (1c), and fluorene (1d) analogues of tilorone dihydrochloride were also prepared. Compounds 1b and 1c were evaluated for interferon induction.
Similar articles
-
An Effective Synthesis Method for Tilorone Dihydrochloride with Obvious IFN-α Inducing Activity.Molecules. 2015 Dec 2;20(12):21458-63. doi: 10.3390/molecules201219781. Molecules. 2015. PMID: 26633340 Free PMC article.
-
[Synthetic low-molecular weight interferon inducers: derivatives of diaminofluoren-9-one, diaminobenzophenones and diamino biphenyls].Arzneimittelforschung. 1976;26(3):312-6. Arzneimittelforschung. 1976. PMID: 989318 German.
-
[Antiviral agents. XIX. Amantadine derivatives and several others].Farmaco Sci. 1977 Feb;32(2):129-40. Farmaco Sci. 1977. PMID: 192582 Italian.
-
The biological activity of the synthetic polyanion, pyran copolymer (diveema, MVE, 46015) and the heterocyclic bis DEAE fluorenone derivative, tilorone and congeners: clinical and laboratory effects of these agents as modulators of host resistance.Pharmacol Ther. 1981;15(1):1-44. doi: 10.1016/0163-7258(81)90014-0. Pharmacol Ther. 1981. PMID: 7038712 Review. No abstract available.
-
Tilorone and related bis-basic substituted polycyclic aromatic and heteroaromatic compounds.Prog Med Chem. 1981;18:135-90. doi: 10.1016/s0079-6468(08)70319-9. Prog Med Chem. 1981. PMID: 7045982 Review. No abstract available.
Cited by
-
An Effective Synthesis Method for Tilorone Dihydrochloride with Obvious IFN-α Inducing Activity.Molecules. 2015 Dec 2;20(12):21458-63. doi: 10.3390/molecules201219781. Molecules. 2015. PMID: 26633340 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Miscellaneous