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Case Reports
. 1981;57(2):220-3.
doi: 10.1007/BF00282029.

SOD-A and chromosome 21. Conflicting findings in a familial translocation (9p24;21q214)

N J Leschot, R M Slater, H Joenje, M J Becker-Bloemkolk, J J de Nef
Case Reports

SOD-A and chromosome 21. Conflicting findings in a familial translocation (9p24;21q214)

N J Leschot et al. Hum Genet. 1981.

Abstract

A balanced maternal chromosome translocation (9p24;21q214) resulted in two offspring with unbalanced karyotypes. One of these, a girl trisomic for both segment 9pter to 9p24 and segment 21pter to 21q214, was found to have a SOD-A activity not significantly different from those found in a group of five cases with trisomy 21. However, clinical evaluation of this girl revealed no symptoms of the Down syndrome. These findings suggest that, providing the gene dosage theory is correct, the gene for SOD-A is probably localized on chromosome 21 proximal to, or in, band q21.

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References

    1. Chromosoma. 1978 Aug 14;67(4):293-307 - PubMed
    1. Lancet. 1979 Jan;1(8107):105 - PubMed
    1. Cytogenet Cell Genet. 1978;22(1-6):521-3 - PubMed
    1. Clin Genet. 1976 May;9(5):483-7 - PubMed
    1. Hum Genet. 1977 Aug 31;38(1):15-23 - PubMed

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