doi: 10.1007/BF02533746.
Sterol-polyene antibiotic complexation: probe of membrane structure
- PMID: 723481
- DOI: 10.1007/BF02533746
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Sterol-polyene antibiotic complexation: probe of membrane structure
Lipids.
1978 Oct.
Abstract
Polyene antibiotics are useful tools for studying the role of sterols in biological membranes. The interaction of polyene antibiotics with membrane-bound sterols in artificial membrane systems, prokaryotic and eukaryotic cells, and lipid-containing viruses is reviewed. The pentaene macrolide, filipin, is shown to serve as a probe of phosphatidylcholine-sterol interaction and of the localization of cholesterol in the membrane of mycoplasmas.
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