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. 1978 Oct;13(10):686-91.
doi: 10.1007/BF02533746.

Sterol-polyene antibiotic complexation: probe of membrane structure

R Bittman

Sterol-polyene antibiotic complexation: probe of membrane structure

R Bittman. Lipids. 1978 Oct.

Abstract

Polyene antibiotics are useful tools for studying the role of sterols in biological membranes. The interaction of polyene antibiotics with membrane-bound sterols in artificial membrane systems, prokaryotic and eukaryotic cells, and lipid-containing viruses is reviewed. The pentaene macrolide, filipin, is shown to serve as a probe of phosphatidylcholine-sterol interaction and of the localization of cholesterol in the membrane of mycoplasmas.

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References

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