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Case Reports
. 1981 Jun;38(6):390-1.
doi: 10.1001/archneur.1981.00510060092022.

CSF perfusion to treat intraventricular penicillin toxicity

J T Callaghan, J I Ausman, R Clubb
Case Reports

CSF perfusion to treat intraventricular penicillin toxicity

J T Callaghan et al. Arch Neurol. 1981 Jun.

Abstract

A shunt infection and meningitis developed in a patient receiving methotrexate intravenously for CNS leukemia. Convulsions and respiratory failure followed the intraventricular administration of 300,000 units of penicillin G potassium. Perfusion with 900 mL of Ringer's lactate removed an amount of penicillin equal to that injected intraventricularly plus some from systemic treatment.

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