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. 1981 Jun;99(6):1090-2.
doi: 10.1001/archopht.1981.03930011090021.

S-antigen uveitis in primates. A new model for human disease

R B Nussenblatt, T Kuwabara, F M de Monasterio, W B Wacker

S-antigen uveitis in primates. A new model for human disease

R B Nussenblatt et al. Arch Ophthalmol. 1981 Jun.

Abstract

Uveitis was induced rhesus monkeys immunized with purified retinal S-antigen. Focal retinal and subretinal infiltration, in addition to periphlebitic changes, were observed histologically. Immunized monkeys had similar cell-mediated in vitro immune responses to the S-antigen as do humans with posterior uveitis. Circulating immune complexes at the time of disease could not be detected. This primate model supports the notion that the S-antigen may play a role in human uveitis.

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