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. 1980 Dec 15;192(3):955-8.
doi: 10.1042/bj1920955.

Differential inhibition of ketogenesis by malonyl-CoA in mitochondria from fed and starved rats

G A Cook, D A Otto, N W Cornell

Differential inhibition of ketogenesis by malonyl-CoA in mitochondria from fed and starved rats

G A Cook et al. Biochem J. .

Abstract

Rates of ketogenesis in mitochondria from fed or starved rats were identical at optimal substrate concentrations, but responded differently to inhibition by malonyl-CoA. Kinetic data suggest that the K1 for malonyl-CoA is greater in the starved animal. These results indicate that, for the regulation of ketogenesis in the starved state, the lower sensitivity of carnitine palmitoyltransferase to inhibition by malonyl-CoA may be more important than the concentration of malonyl-CoA.

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