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. 1981 Jun;73(2):481-3.
doi: 10.1111/j.1476-5381.1981.tb10446.x.

The effects of atropine and oxotremorine on acetylcholine release in rat phrenic nerve-diaphragm preparations

E T Abbs, D N Joseph

The effects of atropine and oxotremorine on acetylcholine release in rat phrenic nerve-diaphragm preparations

E T Abbs et al. Br J Pharmacol. 1981 Jun.

Abstract

1 Atropine (10(-5) M) enhanced the release of [3H]-acetylcholine from rat isolated hemidiaphragms, previously incubated with [3H-methyl]-choline, stimulated via their phrenic nerves. 2 Oxotremorine (10(-5) M) did not affect the stimulated release of [3H]-acetylcholine but antagonized the facilitatory effects of atropine (10(-5) M). 3 It is suggested that there are presynaptic inhibitory muscarinic receptors that modulate the release of acetylcholine in the phrenic nerves of the rat.

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