[A correlation between the histological parameters such as stromal reaction and cell-mediated immune-structure of the regional lymph nodes, and the delayed cutaneous hypersensitive reaction toward DNCB in cervical cancer (author's transl)]

Abstract

We have studied a correlation between the histological parameters such as stromal reaction to cervical cancer and cell-mediated immune response of the regional lymph nodes designated as lymphocyte depletion, unstimulated, and lymphocyte predominance pattern which were thought to reflect the cell-mediated immune reaction to cervical cancer and the DNCB skin reaction in 84 patients. 1) Group with DNCB skin reaction negative (20 cases): Eight showed no or only the slightest trace, 7 moderate degree, and 5 marked degree of the stromal reaction. The immune response of the regional lymph nodes were 4 of lymphocyte depletion, 6 of unstimulated and 10 of lymphocyte predominance pattern. 2) Group with DNCB skin reaction positive (64 cases): This group showed 7 cases with no or only the slightest trace, 30 cases with moderate degree and 27 cases with marked degree of the stromal reaction. In this group, 6 had the regional lymph nodes of lymphocyte depletion, 10 unstimulated and 48 lymphocyte predominance pattern. 3) There was a significant correlation between the DNCB skin reaction and the degree of stromal reaction (p less than 0.05), but no correlation between the DNCB skin reaction and the regional lymph node morphology was found in this study (p greater than 0.05). 4) The discrepancy between the stromal reaction, the lymph node morphology and the DNCB skin reaction was discussed in relation to the significance of these parameters.