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. 1981 Feb 1;153(2):494-9.
doi: 10.1084/jem.153.2.494.

Induction of fibroblast chemotaxis by fibronectin. Localization of the chemotactic region to a 140,000-molecular weight non-gelatin-binding fragment

A E Postlethwaite, J Keski-Oja, G Balian, A H Kang

Induction of fibroblast chemotaxis by fibronectin. Localization of the chemotactic region to a 140,000-molecular weight non-gelatin-binding fragment

A E Postlethwaite et al. J Exp Med. .

Abstract

Plasma and cell-derived fibronectin are potent chemoattractants for human dermal fibroblasts in vitro. The chemotactic property of fibronectin resides in a major 140,000-mol wt non-gelatin-binding fragment of the native molecule. Human monocytes and neutrophils do not recognize fibronectin as a chemotactic stimulus. These findings suggest that fibronectin and perhaps certain fragments of fibronectin may function in vivo as a specific chemoattractant for fibroblasts and could, therefore, induce directional migration of fibroblasts to sites of tissue injury, remodeling or morphogenesis.

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References

    1. J Exp Med. 1973 Feb 1;137(2):387-410 - PubMed
    1. J Biol Chem. 1980 Sep 25;255(18):8848-58 - PubMed
    1. Proc Natl Acad Sci U S A. 1975 Aug;72(8):3158-62 - PubMed
    1. J Exp Med. 1976 Jun 1;143(6):1299-307 - PubMed
    1. J Exp Med. 1976 Nov 2;144(5):1188-203 - PubMed

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