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Comparative Study
. 1981;19(2):101-7.
doi: 10.1007/BF01324226.

Increased radioresistance of cells in cultured multicell spheroids. I. Dependence on cellular interaction

H Dertinger, D Hülser
Comparative Study

Increased radioresistance of cells in cultured multicell spheroids. I. Dependence on cellular interaction

H Dertinger et al. Radiat Environ Biophys. 1981.

Abstract

Monolayers of six different cell lines were investigated with respect to ionic coupling using micro-electrode techniques. In parallel, survival after Co-gamma-irradiation of monolayer- and spheroid cultures of these lines was compared. It was found that spheroids of coupled cell lines were more radioresistant than monolayers ("contact effect"). however, cell coupling did not enhance the survival of monolayers over single cells. This suggests that the contact effect is a "tissue phenomenon" requiring cellular interaction but is expressed only under conditions of three-dimensional growth.

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References

    1. Radiat Res. 1973 Dec;56(3):513-27 - PubMed
    1. Int J Radiat Biol Relat Stud Phys Chem Med. 1975 Sep;28(3):255-65 - PubMed
    1. Exp Cell Res. 1977 Jan;104(1):153-63 - PubMed
    1. Proc Natl Acad Sci U S A. 1977 Oct;74(10):4476-80 - PubMed
    1. Radiology. 1973 Feb;106(2):447-9 - PubMed

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