Chronic nonpulsatile blood flow in an alive, awake animal 34-day survival

Abstract

Most acute studies of nonpulsatile blood flow have shown effects on systemic organs. There have been few long-term studies of the effects of nonpulsatile blood flow due to lack of an appropriate experimental model and, consequently, it is unknown whether mammalian physiology can adapt to chronic nonpulsatile blood flow. The following case report documents the effects of chronic nonpulsatile blood flow in an alive, awake animal maintained with fibrillating ventricles for a period of 34 days.