Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1981 Apr;11(1-2):28-32.
doi: 10.1007/BF01991450.

In vivo formation of histamine phosphopyridoxal cyclic compounds

D Kierska, K Sasiak, C Maśliński

In vivo formation of histamine phosphopyridoxal cyclic compounds

D Kierska et al. Agents Actions. 1981 Apr.

Abstract

A possibility of in vivo formation of cyclic compounds between histamine (Hi) given i.p. and endogenous pyridoxal (PL) or pyridoxal 5'-phosphate (PLP) has been studied. Cyclic compounds of Hi with PL or PLP were found in all tissues examined. Although an increase in Hi levels in tissues enhances the formation of cyclic compounds, no simple relationship between the rate of formation and Hi concentration has been observed. The reaction seems to be limited by endogenous PLP. The cyclic products Hi-PL and Hi-PLP were discovered in urine. It is suggested that the process of cyclic compound formation may reduce PLP resources, resulting in a modification of PLP-enzyme activities.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Agents Actions. 1975 Feb;5(1):15-9 - PubMed
    1. Agents Actions. 1977 Mar;7(1):19-25 - PubMed
    1. Nature. 1977 Oct 13;269(5629):617-9 - PubMed
    1. Life Sci. 1978 Jul 24;23(4):375-82 - PubMed
    1. Agents Actions. 1975 Dec;5(5):471-5 - PubMed

LinkOut - more resources